I think it has the same humor, but a little bit less of it. He has some one liners, but you have to remember that it's ten years later and he's been living the lie without killing.
The only thing that I wonder about is how they are going to approach the main killer. As you might remember, each season of Dexter had that main killer arc (Ice Truck killer was first season, Dexter/Doakes was technically the killer of the second, the District Attorney guy that got hooked to killing was the main killer of the third season, and the Trinity Killer was the main killer of the fourth season). I think we are six episodes in of New Blood, and Dexter has already discovered the main killer without any investigating since he's been killing for as long as he has.
Another thing I wonder about is what they will do moving forward if the series is renewed. Believing a huge city like Miami having all these killers is one thing, but a small rural area in New York having more than one? I'm not sure about that one.