Quantum Chemist is nice, seeing as I drunk/sold most of the Quantums early on. I love Puppies! too, and apparently Nuclear Anomaly makes you invincible, if you are are poisoned by rads. Deep Sleep, Nerves of Steel, No Weaknesses, Party Boy/Party Girl, Rad Absorption, Rad Tolerance, Warmonger are all useless. Almost Perfect is useless too, if you thought out your character ahead of time. Devil's Highway, Escalator to Heaven, and Karmic Rebalance are only good to get the achievements.
Really only two good perks. I say just catch up on missed perks.
Yes.