Nobody is taking effect the fact that there are different button layouts. John, the three people who answered are correct, but that is for default. If you have a different button layout go to the options, button layout option screen and see which button layout your using to pick it up. And also, another thing is that it won't say 'Hold (Button) to pick up Skull' you will just have to be ontop of it and press the button to pick it up with your button layout.
Signature and avatar done by Vasco the noob.