Wesker would be cool, his Up attack could be an uppercut, his down he could pull out his handgun and fire a few shots.
While his side attacks could be a charge punch which launches him across the stage, throwing anyone caught above him, or he grabs them by the face and slams them into the floor.
His final smash could be that he dashes around the stage at high speed grabbing anybody along the way and throwing them or he could call the Tyrant to attack.
That would be cool.
Credit to .Impact for the sig & avy